I Have A Super USB Drive

The next day, in the Zhongzhou Academy of Sciences-Shangdu Life Science Research Institute.

At around seven o'clock in the morning, five or six male and female employees were wiping tables and chairs in a meeting place, while they were chatting about the Internet in their spare time at work.

Because it was not time to go to work, from time to time, the girl's crisp laughter came from the meeting place, bringing a touch of freshness to the quiet and solemn research institute.

Until 7:30, everyone will wipe away the dust falling in the arena and begin to wipe the windows and railings.

"Why haven't you finished?"

At this moment, a middle-aged man in a straight suit rushed in urgently, "Hurry up, I will use this venue at eight o'clock!"

"Group leader, don't worry, the cleaning can be completed before eight o'clock." A young girl replied with a smile, "Why are you in such a hurry."

"What do you know?"

The middle-aged man looked even more anxious, "I just received the news that the dean and the deputy dean came to this venue. Don't you know that the dean is used to arrive ten minutes earlier?"

Everyone was shocked, and quickly accelerated their movements.

Just when the middle-aged man was in a hurry and even prepared to roll up his sleeves, there was a sudden sound of footsteps behind him.

The middle-aged man turned his head subconsciously, but saw a young man in a white shirt approaching, "Excuse me, is this meeting room No. 3?"

"Yes, are you?" The middle-aged man saw that the young man was a little stunned and realized that he was not a person in the hospital, so he subconsciously glanced at the work permit on his neck.

Chen Chen?

Never heard of...

"I am the speaker of this conference." The young man named Chen Chen glanced inward, "Can I go in now? I want to prepare in advance."

"Oh, yes, please come in..."

The middle-aged man quickly stepped aside and was a little surprised as he watched the young man step onto the podium skillfully and began to adjust the projection equipment.

It was the first time that he saw such a young face standing on that podium, not to mention that this time the dean was personally supporting him.

Everyone who cleaned the venue looked at the young man curiously, and did not dare to continue talking. The movements in their hands accelerated a bit, but the venue was cleaned up in ten minutes.

The middle-aged man secretly breathed a sigh of relief. He glanced at the podium one last time, and saw that the young man was still checking the PPT with a serious expression on his face, and he gave everyone a gesture, preparing to exit the meeting.

However, just when he was about to take everyone away silently, his heart suddenly became tense.

On the corridor, the dean and a large number of academicians had already walked towards here.

"Hurry up!" The middle-aged man hurriedly shouted at the crowd, and a group of people quickly left.

A few minutes later.

In the venue, a group of men with different looks in work clothes entered the venue. Although they have not yet begun to speak, these people are still sitting quietly in their seats, showing excellent qualities.

This group of people are not students, but a group of middle-aged and elderly people over fifty, and some even over sixty.

However, unlike ordinary middle-aged and elderly people, everyone here is at the top level in the academic world, and a few are famous all over the world.

These people are basically academicians of the Chinese Academy of Sciences, and the others are also senior managers like Wang Luo.

What Chen Chen has to do is to persuade this group of top elites in academia, because only this group of people who recognize the feasibility of Chen Chen's plan can be regarded as an explanation to the government, and Professor Wang Xi will agree to go abroad for treatment.

Looking at the already full meeting place, Chen Chen bowed slightly and began to speak with a long breath:

"The so-called Alzheimer's disease is a devastating neurodegenerative disease, which occurs mostly in middle-aged and elderly people. On average, there are 5 to 8 patients out of every 100 people over 60 years old, and as the world ages This number is still increasing exponentially."

"Unfortunately, more than half of the world's people don't understand this disease. In the context of rapid medical advances around the world, Alzheimer's disease has become the only disease whose mortality rate has increased in the past decade."

As Chen Chen spread his hands, the big screen behind him kept showing the reports intercepted from various newspapers and periodicals.

The data in these reports is shocking.

"Alzheimer's disease, here I am referred to as AD for short, I believe that some people already know it well, after all, there are only two main complications: Aβ protein deposition and Tau protein mutation."

"But until we investigate deeply, we will find that the clues inside are extremely complicated. Behind the two complications, there are countless factors at work, just like endless coils of thread twisted together..."

Chen Chen pointed to the screen behind him, "So far, the most in-depth discovery in the academic world is probably microglia. As a type of brain immune cell, experiments have proved that microglia can effectively swallow Aβ after being activated. Protein and abnormal Tau protein, inhibit AD symptoms."

"But at the same time, this immune cell is a double-edged sword."

Chen Chen turned around, and the screen behind him showed several research reports. "Recent research has shown that microglia not only engulf abnormal proteins, but also secrete a substance called apolipoprotein E, which is ApoE. "

"The gene responsible for the secretion of ApoE has three conformations, ApoE2, ApoE3 and ApoE4. Each person's body of this protein gene takes two or two groups, and each person can only have one or two of them."

A list automatically appeared behind Chen Chen, "In other words, in everyone's body, the probability of your genetic combination is about one-sixth."

"ApoE originally helped to remove Aβ deposits, but in subsequent studies, scientists discovered that E2 is more effective than E3, while E4 has the opposite effect and will increase Aβ deposition."

"Having a copy of the E4 gene will increase the risk of AD by 3 times, and if the gene sequence in your body is [E4/E4], then congratulations, your risk of AD is 12 times that of ordinary people."

Following Chen Chen's words, there was a quiet conversation from the audience.

"Microglia not only affect the deposition of Aβ protein, but also affect the mutation of Tau protein."

Chen Chen spread his hands, "The mutation of Tau protein phosphorylation can cause neurofibrillary tangles, which will cause the death of nerve cells. But how does this death happen?"

"The result of today’s research is that this kind of death may still be caused by microglia. When it attacks those tangles, it will damage nearby neurons. At the same time, APOE4 secreted by microglia will also amplify the Tau protein pair. The toxic effects of neurons."

"Therefore, after genetic identification of patients, can we restrict or activate microglia based on the patient's genes?"

Chen Chen followed good advice, "and my Black Light Biological Research Center is based on this."

Several elders in the audience glanced at each other and nodded approvingly.

Chen Chen uploaded the information and photos in his hands to the projector, “In AD complications, inflammation is always associated with it. In recent studies, it was found that a cytokine of IL-1β can cause inflammation, while IL- The increase in 1β cytokine is due to the sharp decrease in TOM1 protein..."

"The paper published in "PNAS" confirmed this view. After the expression of TOM1 decreased, the Aβ protein in the brain of AD model mice did increase, and the cognitive ability of these mice also declined. "

"So, during my experiment, I used gene overexpression to activate the TOM1 protein gene, which greatly improved the condition of the experimental body."

Chen Chen uploaded the experimental materials one by one, “You can imagine TOM1 as the brake structure of a car. In the brains of AD patients, this brake fails. What we have to do is to repair this brake at the molecular level.”

Everyone's expressions moved upon hearing this.

"Through the first two methods, we have temporarily suppressed the condition of AD, but if we do not find a solution in this way, the result can only be tragedy, then what we have to do next is to eliminate the deposition."

"Therefore, the third item of our research center is developed by Eli Lilly. This is a monoclonal antibody against Aβ peptide chain, which prevents its deposition and polymerization, and can eliminate it from the human brain."

"Of course, this is not enough, so we have the last and most important process-the production of autologous neural stem cells through'induced pluripotent stem cells', while activating the G2 resting stem cells of the human brain."

"Through this form, we can restore the brains of AD patients again. Even if it does not return to its original state, it can still recover to a large extent."

Following Chen Chen's words, photos and evidence after the animal experiment appeared on the screen, everyone in the audience finally couldn't help but began to discuss in a low voice.

"I will publish these results in "CELL" in the future. If you are interested, please contact me. I can provide you with detailed data."

With that, Chen Chen turned off the projector, turned and walked off the stage.

Papa papa papa...

There was a round of applause.

Seeing this scene, Chen Chen couldn't help but remember the scene when Professor Wang Xi was giving a lecture to himself.

More than a year ago, I was still sitting in a university class, listening to Professor Wang Xi's mouthful of driving the train, and constantly instilling forward-looking remarks into my group of students.

At that time, the lifelong goal of many people was probably to become an academic expert like Professor Wang Xi in 20 or 30 years, right?

But I didn't expect that after just over a year, I would stand on an almost equal position with Professor Wang Xi.

However, this is just the beginning...

Chen Chen thought silently.