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"Nature" magazine published several papers on rapamycin in 2009.

Some scientists divided nearly 2,000 mice that were 20 months old and 60-year-old humans into two groups. One group had food mixed with rapamycin and the other group did not.

In the final experiment, the results were unexpected. The life span of the mice ingesting rapamycin increased by an average of 14% compared with the other group.

In the last century, scientists discovered two ways to prolong the life of mammals, one is to "repair" genes, and the other is to reduce fat intake by controlling diet.

Naturally, there is no need to say more about the method of repairing genes, that is what Medpod 3000 can do.

The purpose of reducing fat intake is to reduce the activation of a protein molecule called TOR.

TOR is a signal molecule originally secreted by the human body, which can regulate the growth of each cell of eukaryotes. When TOR is activated, it will cause the cell to synthesize biomolecules, increase the cell mass and volume, and synthesize protein and nucleic acid. Increase, promote the cell to become bigger and heavier.

If you compare a person to a large and sophisticated machine, even if the energy source is constantly taking in energy from the outside world, the various “parts” in the body will wear out with the years of use, and the activation of TOR is like meeting the basic needs of life. Extra work overtime on parts makes the machine age faster.

The reason why rapamycin can prolong the lifespan of the mice is probably because it "deceives" the mice's body, making the mice believe that the fat intake is reduced.

Of course, all of this is not supported by any human clinical trial data, and all applications for clinical trials using rapamycin to extend lifespan have been officially rejected.

Even so, in the period from 2010 to 2020, you can still hear the gossip of many doctors taking rapamycin secretly.

However, after ten years, rapamycin, the "life-prolonging medicine", has overturned again.

"Journal of Clinical Medicine" published a paper in April 2020, claiming that too low TOR activity will trigger the aging of the hematopoietic system.

In short, at the cellular level, inhibiting TOR can deceive the body and delay aging, but in the hematopoietic system, it needs TOR activity to support itself.

Excessive inhibition of TOR will directly cause the senescence of the cell niches in the bone marrow, which will lead to the aging of the hematopoietic stem cell function.

In fact, Chen Chen also considered improving rapamycin or using drugs in combination to offset the side effects and find a specific drug to extend life.

It was only later that Chen Chen discovered that in the field of stem cells, the effect on the human body was far greater and more potential than this drug, so he gave up rapamycin and turned to specialize in stem cells, and finally researched the reversal of aging. Treatment items.

Now, in the face of immunosuppression, Chen Chen once again thought of this legendary drug, which can be regarded as a historical retrospective.

For the next half month, Chen Chen picked out a clone and gave it a daily synergy of rapamycin, cyclosporine A and FK506. The three drugs were used in combination, and the clone’s immune coefficient was quickly completely improved. Suppressed.

After the clone's immune system was suppressed, Xiao X extracted his clone and placed it on the stretcher again.

This time, the clone injected was no longer T-002, but after two failures, another improved T-003 was carried out.

Compared with T-002, T-003 virus is more complete, knocking out two RNA errors, and more in line with Chen Chen's genes.

Sure enough, in the face of T-003, although this clone had already suppressed the immune system, it easily broke the record of three hours and twenty-eight minutes for the previous clone, and did not die for six hours after the virus was injected.

Not only that, because the DNA in the clone is undergoing earth-shaking changes, Xiao X constantly injects a large amount of nutrients such as glucose and carbohydrates into the clone to prevent the clone from dying on the T virus, but on the nutrition. Bad above.

In Chen Chen's eyes, this clone was swelling almost at the rate of a steamed bun fermenting, and soon grew to a height of two meters. The whole body was tangled like a tyrant with a small size.

This is the first time Chen Chen and Xiao X have seen this situation.

However, the clone eventually died. After all, his body has not survived the transformation of the T virus, but it is worth celebrating that the clone persisted for a total of eight hours.

The extension of time gave Chen Chen new hope.

Seeing that it eventually became a clone of a zombie, Chen Chen looked thoughtful, "Although it still failed, this experiment is very meaningful."

"Yes, there is no problem with our direction."

Little X, while controlling the black knight to collect the clone’s DNA, said, “Rapamycin can effectively inhibit the body’s rejection of the T virus. Generally speaking, the behavior of suppressing immunity is indeed a death. After all, the immunity of ordinary people. It can't compete with T virus at all, and suppressing immunity will only make people die faster."

"However, if this T virus matches the host's DNA, it is a completely different result."

With that said, Xiao X compared the DNA of Chen Chen’s tyrant clone with the DNA of the latest zombie clone, “Look, we are getting closer and closer to the correct answer, but we only have A mature clone is now, and a new batch of clones will take six months to mature."

As he said, Xiao X became distressed, "Moreover, the closer the improved T virus is to the formula, the slower and slower the progress.

"It's normal."

Chen Chen nodded, "It's like a game. Modifying a BUG will inevitably generate a new BUG. Although the code can be continuously modified to make the game close to perfection, as the game becomes more and more perfect, the difficulty of modifying the BUG It will inevitably increase. These are all related to the whole body...

"So, in the end, you have to try your luck?"

Little X asked.

Chen Chen nodded and sighed, "It's like the original ancestor virus was improved into a perfect T virus, which contains the ingredients of luck. And many special medicines in the world are not designed for this disease. They The appearance of is a kind of luck in itself."

"It can even be said...Scientific research itself has a certain element of luck. This is something that cannot be avoided, but the diligence and ability of scientific researchers can make up for this kind of luck."

"After all, luck will not always be on our side, but hard work and ability can..."

After thinking about it, Chen Chen added again, "Of course, money is also possible."

Little X: "..."

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