Parallel World Pharmacy

Early in the morning, Pharma, who revealed the night in the professor's office, finally solved a misunderstanding between Pharma and Ellen and her bowling secretary Zoe, and saw that she had returned to the secretary's office, began to panic after looking at the clock in the professor's office.

"Not good, it's time for the pharmacy to open. Ellen, do you have a lecture today?

"Well, I have an internship class in theology in the morning, so I can't go to the pharmacy, can I? What am I supposed to do, open a store with only part-time pharmacists?

Once a week, Ellen had a lecture in the morning on theology internship and was looking forward to it.

Physical education for aristocrats as usual, equivalent to classes. In my first class, I played a divine game against everyone, etc., so I guess the divine internship is a little place for a change of mood for Ellen, who is experiencing more deskwork and lack of exercise, Farma thinks. Incidentally, people of civilian origin have another menu exercise available because they can't use theology.

"I'm setting up a little experiment right now, too, so I can't get my hands off you. My brother said he was free today, so let's ask for a surrogate."

When Pharma remembered and wrote a note, he borrowed a college biographical dove to fly a letter to the Medicis family. When I'm busy with college lectures, preparation, etc., Palle helps me practice pharmacy, or even represents me in lectures.

"Are you sure? Palle, wouldn't you be mad if I asked you to be so carefree later?

"My brother needs the number of cases, so he asked me to turn them around."

Palais is a first-degree pharmacist, so it is common to see royal marquis nobility at visits, but it is beneficial to practice at pharmacies. Because first-level pharmacists have the practice norm of having to see how many cases a year.

If you seem to be well below that norm without any particular circumstance, you may be demoted to a secondary pharmacist as inexperienced. Palle was unable to practice while he had leukemia, so he treasured a part-time job at a different world pharmacy where the patient could give him a leg and earn the number of cases at once.

"Oh, the number of cases does. I haven't had a problem since I started working at the pharmacy either. More than a hundred people come every day, and I've had a lot of practical experience."

Ellen, too, was a part of what I appreciated from day to day.

Soon after, the pigeon at the mansion replied, and Palais seems to be taking care of me all day today.

"By the way, Farma, how was Holy Springs? Was there anything dangerous?

The two finally get to their respective jobs and Ellen asks Farma how they were last night. Ellen does not know what is in the Holy Springs and what is the place to do. However, the fact that it is a serious sacred site about the secrets of the patron saint is in her head.

"When it comes to danger, it was dangerous... but there's a lot more unexpected than that."

Farma was in havoc when she told Ellen the genetic analysis results of the Emerich clan, while successfully laying low the story of a laboratory in different worlds.

"Huh? Emerich, have you been reading all of your genomic information?

"Yeah. I can do it on PCR, but there's a way to read genetic information on a larger scale."

Pharma touches the PC he brings back from the otherworlds and exchanges words with Ellen in a hurry for genetic analysis. Farma misses the feeling of hitting the keyboard with Katakata.

It's been a long time since I've worked on a PC screen, and I have severe eye strain, but from my previous analog life, I have exceeded my level of progress. Even as Pharma, I was just thankful to have access to the instruments of civilization.

Ellen goes mid back, like incredible, while reviewing textbooks.

"Wait... there are three billion base pairs of human genome information or something. You mean you read it all? How?

Ellen had her glasses slipped off and fell to the floor.

Fortunately, the glasses didn't break because the professor's office was carpeted.

"Take care of your glasses"

"Hey, do you have a treasure in Holy Springs that can do that? Really?"

"Well, that's the place"

Details of the genetic analyzer that can be analyzed on a large scale in the laboratory should be kept cloudy.

Did Ellen go from stunned to desperate when she heard of her treasure and was accepted?

"Well... Emerich, you inherited all of your clans... I'm glad Lotte didn't, but it's just hard to tell what's going on in the future. He thought he was going to kill himself before he developed, and I wonder how I could tell him the results."

Fortunately in my misfortune I found out I didn't inherit it it from Lotte.

But Ellen also seems to have no choice but to watch her godson suffer from death and illness.

"Well... it looks like my second son is already sick. I just don't have any symptoms."

With that said, Pharma is staring at the monitor portion of the laptop he took home.

Ellen noticed ahead of Pharma's gaze and gazed.

"By the way, Pharma, you're watching, I can even see that. Glow what?

"Uh, Ellen, can you see this?

"I can see it. Luminescent, square and translucent. Did you bring it from Holy Springs?

Ellen peeks into the laptop that remains up and running from behind Pharma. Ask Ellen, strangely enough, only the LCD surface seems to be visible.

"I brought it from Holy Springs. I've treasured it and the monitor is a little too clear for me to see. So, you don't see this?

Pharma tried to close the display portion of the laptop with a patan.

"That, I can't see. Where did you hide it? Strange!"

Ellen is slight, but of course she looks like Pharma. They don't look like people except for the LCD display. Besides, they don't seem to touch it. It was great for preventing theft.

Pharma opens the display with confidence. I have trouble seeing anyone.

"This is the way it's really shaped."

Pharma writes a schematic diagram of the laptop on paper.

Ellen roared, "I can't see you at all." She thinks of it as a treasure, so she doesn't hear more about how it works or anything. On the contrary, thank God for Pharma.

"There's a letter in the universe that I've never seen... Farma, can you read this? What are you doing, man?

"I'm calculating. I'm analyzing the genetic information."

"Farma, you. What the hell kind of advanced civilization do you have... you really know everything"

If it's Ellen, you can be seen, and Pharma hits the command line explaining it without any particular vigilance.

"There's more I don't know, and I'm buying too much. And about this illness."

"You did. Farma, did you come up with a cure for lethal familial insomnia? Me too, I've been thinking a lot... Will you look at that?

Ellen shows Pharma the idea notes she's been thinking about all night.

I guess I took quite a while to think about it, dozens of pages, the various ideas had been thoroughly twisted out, but nothing seemed to be possible to adopt. Nevertheless, even on modern Earth, no cure was found until just before Pharma was reincarnated, so Ellen's stuck can be considered reasonable.

"What do you think? Was it going to work?

Ellen asks innocently if she has any tips. Ellen is an elite pharmacist in this world, but only against Pharma, so she goes into student mode.

"Uh... yeah, thanks. It'll help."

Farma's reaction is not aromatic, so Ellen shyly snatches back her idea notes.

"That. I'm sorry, I can't help you..."

Ellen covers her face with both hands. That was already depressing, like a student with a red dot.

"No, some of it was a shame. Thanks!"

Pharma encourages Ellen, but has a bad tooth cut.

Ellen sighed one thing and regained her mind.

"Then I guess I'll hear Professor Farma's answer. You said to Pharma, Emerich,” I just need to cure the genetic mutation before it develops, "right? How do you do that?

If the gene is the original of the organism's blueprint, the genetic mutation is the misplaced original of the information.

Once you make the protein as that info suggests, you keep having pathogenic prions.

Ellen seemed to understand that the original had to be fixed.

"Oh, that's right. I didn't write it in my textbook... I can delete, substitute, and insert genomic DNA at the desired site, using a technique called Crisper Cas9 (CRISPR/Cas9)"

A set of reagents to carry out that technique is already in Pharma's possession by taking it out of the lab.

It was not until the early 2010 's that this new technology was found, and its rapid diffusion as a genome-editing technology, and its lifetime pharma was also abundantly involved in its research.

"Emerich, you're saying there's a way you can rewrite and cure the genetic mutations that cause the disease you're suffering from?

"Yeah, well, to put it bluntly. The virus loaded with that system is infected with cells throughout the patient's body to make it work. This is the preparatory phase"

"If you let the virus infect your whole body, you'll die of an infection!?

"You're right about pathogenic viruses. But there's a virus called the Adeno-associated virus, and it's hardly pathogenic. Use it."

"Some viruses aren't toxic..."

Ellen seems to recall that the virus makes a difference in pathogenicity.

Nevertheless, Pharma is not at all worried about the risk of the virus either.

In the unlikely event that a virus infection is likely to become more severe, Pharma will mark the virus and will disappear from virus to virus if the substance is used to eliminate it, so safety measures can be prepared.

"I mean, you have to have someone other than me do the manipulation of adding more viruses."

"What, me? No, I'm not sure."

Ellen has eyes with Pharma and she can't, she's shaking her head.

"Something that's going to make you feel better. The virus is going to flip and smash and infect everyone else."

Watching the glasses handled was definitely a pharma I think......

"Please be careful. I'll kill the virus and the bacteria in the sanctuary, so I can't add more and I can't handle it anymore, I regret it."

The sanctuary Pharma has is also a troubled one, and Pharma is no longer likely to be involved in research that exploits the nature of viruses and bacteria to genetically manipulate them.

"Something, Farma. Poor you."

I'm sympathetic to Ellen, but the pharmacist's ability to make me cry, Farma won't hang up.

"Well, leave the virus story alone. It gets a little complicated, so I guess I'll use this hippo to explain how genome editing works."

Pharma doubled the leeches for the luggage that were nearby to explain to Ellen.

Mark around the middle of the string and hypothesize there as the genetically mutated portion of the Emerich clan.

"Once the virus is systemically infected, the RNA that was designed to detect the genetic mutation on board the virus binds to the genome, and the enzyme marks it to cleave the mutant portion of the gene"

Pharma shows Ellen the string, with a knife, and slashes the two strings together so as to pinch the genetically mutated part.

"Is that it? Can I leave this string uncut? That means we're out of DNA, right? This is a big problem with the genes being destroyed, isn't it?

Ellen turns her gaze to the cut end of the chopped string.

"Of course it's not good if you leave it hanging up. But the biological system is great, and the genetic repair system repairs it at will. When you get your DNA repaired, if you mix in the sequence you want to change, you get it taken in too."

To the region corresponding to the cleaved genetic mutation portion, Pharma appreciated a short ribbon and tied the ribbon between the string and string to make up for the missing information, which was found in the normal genetic region.

"Where did this ribbon for incorporation into the genome come from?

"Keep this on the virus, too. Now, the genome has been repaired to the correct sequence to become a normal prion gene. The bad news is, nowhere else."

"What, that's not it?

Ellen widened her eyes.

"Anyone who hasn't developed a disease yet will be cured with it."

"You mean you won't be a patient anymore, right?

Ellen confirms with care.

"Now he and his descendants will be released from the curse"

She received Pharma's chopped, genome-looking string, which she checked with tightness.

"Does that mean it's healed...? Did you say you rewrote the genes? Farma, if you say so already. I don't know the cure. Not much."

and Ellen, connecting Pharma as relieved,

"I hope so."

Pharma said so and put a cheek wand on her troubles.

"Actually, maybe this isn't how it works."

There were reasons why I couldn't be optimistic.

"Where do you think it's not going to work? It sounds perfect from me, though."

"The brain, the spinal cord, each organ has a biological defense mechanism to eliminate the virus, and it's not like the virus can infect 100% of the organs and tissues of the whole body, and it's not 100% efficient for genes to be able to alter even if they go into more cells. I mean, I can't really genetically alter it, I can take it away."

"So there are still cells that are untreated, and abnormal prions continue to be made of untreated genes."

Additionally, there was a risk that genetic sequences other than the target, similar to the target, would also be rewritten, but Pharma would not be so problematic about it as it had produced improved enzymes thousands of times less erroneous than conventional ones, so I kept my mouth shut about it.

"By the way, we just need to get a set of enzymes for that genome editing to the cells all over the body, right? You don't have to use a virus for that, do you?

"If you don't use the virus, it's hard to get into cells all over your body. Anyway, the drug diffuses and thins."

It's the hard part of gene therapy that drives drugs and therapeutic factors all over the body.

There's another way.

Ellen approached Farma's professor's desk and peered directly into him.

Seeing Pharma so meaningfully, Pharma becomes stubborn.

"What?"

Ellen took Pharma's hand in vain and let him raise his hand around his clavicle.

"Heh? Hey, what are you doing?

Pharma is frightened and confused by the feel of her skin. Ellen pressed Farma's hand hard against her body as she seemed to illuminate.

"Ah..."

Pharma's hands are clear and into Ellen's body.

"Look, this is how it works"

Ellen made a sweet voice.

"If I hold the cure in your hand and stick my hand in the patient's body and stir it, the medicine will be all over the cells, won't it? Physically. If you're still not genetically modified efficiently, even if you can't cure it in one go, if you do it a few times, you're cumulatively close to 100%, right?

Farma is overwhelmed by the thought of something amazing.

It overshadowed the common sense of gene therapy that had almost solidified in Pharma, and the idea was flying.

"Sure, there is. Not a cure, though."

It was a cheesy idea, but it worked great.

I might be able to solve the part of modern medicine that was a necklace.

"Good. One idea has been adopted, I think it's a bit cheating."

Ellen seemed happy.

"Your second son has already started to accumulate abnormal prions, so we have to do something about the abnormal prions produced."

All abnormal prions must be removed because abnormal prions are changed to abnormal types. As for the removal of the abnormal prion, it seemed possible to overcome it with Ellen's idea.

Antibodies that label and bind abnormal prions are diffused throughout the body with Pharma sticking his hand into the patient's body. If the antibody is fitted with a special landmark substance that is not found in the human body, Pharma can use its ability to erase it for each abnormal prion.

Both normal and abnormal prions will temporarily disappear from the whole body, but prion proteins normalized by gene therapy will soon begin to be produced.

My second son is going to be able to treat me with this.

It will take some time, but if Emerich's clan boils well, this will save everyone.

By healing all germ cells, their children and grandchildren don't have to be frightened by the fear of onset.

(Pretty sweet estimate of the risk, but... a little better than God's favor.)

Since there is no precedent for the method of administration, I can't imagine what would happen if it failed.

Systemic gene therapy has just finally begun in animal experiments. Not yet successful in humans.

Still, when it comes to my second son, I have no other choice than to do it, and it would be better than not to do it. Besides, even if the worst genome editing efficiency is worse than I expected, as long as Pharma continues to erase aberrant prion proteins, we can slow the progression of symptoms to almost no different from that of healthy people.

Pharma summarized the results of the genetic analysis and summoned Emerich to the teaching room in conjunction with the treatment policy. Ellen was also present.

Emerich seemed unable to hide his shock when he knew that the hereditary disease of death had been inherited from the entire clan, but he seemed to find a light of hope in the cure offered by Pharma.

"Are you saying that once you combine your professor's divine art with the technology to modify that gene, you might be able to root out it?!

I wonder how pleased Emerich was, jumping out of the chair and expressing his joy all over his body.

"Maybe, but"

Be careful not to delight in Pharma.

"Tell me about that divine art, too!

"I can't do that. Because I can't use my magic for any other pharmacist."

Emerich didn't seem to understand what that meant. Explain, however, that Pharma is a special attribute of theological use.

"Does that mean that Professor Medicis' attributes are close to unattributed… I see, when you paired them with your professor, you couldn't read the attributes of theology"

Emmerich was impressed.

"But then no one can be treated except the professor..."

As for Emerich's clan, it may be curable.

But I hope Emerich feels like he can't do that, as a single pharmacist.

"That's the thing. That means that the cure for this disease is still equal to not having established"

Farma said frankly.

We cannot save future generations of patients in a way that becomes unusable for one generation only.

The treatment must be scientifically evident and evaluated in clinical trials and can be handled by other pharmacists. If it wasn't a technology that anyone could handle, it wouldn't have set up a cure, Farma said.

To Emerich, too, Farma's intentions seem to have been conveyed with a hint.

"I'll see for myself if this policy is feasible. Specifically, use plants and small animals for preliminary testing. If that goes well, give it to your second son. If your second son does well, I'll give it to other families, including you."

Emerich was quietly listening to Pharma's plan. And I looked at the ceiling blurry.

"Mr. Emerich? What's the matter with you? Did you get the story?

Ellen pounds on Emerich's shoulder, which also seems to be in the sky at first sight. He doesn't when he asks if he didn't understand the story.

"So, is that a good policy?

Pharma confirms. Of course, I intend to explain it to each and every member of Emerich's family and take their consent.

"Thank you. With the professor's divine art and latest technology, please save your sisters, thank you. Thank you."

Emerich took a big, deep breath and closed his eyes to stifle Pharma's words.

(Hmm? You said your sisters, right? What about yourself?)

Pharma was caught by Emerich's rhetoric.

"Professor, I've made up my mind"

"What?

"My genes, do not heal. I'll untie this curse myself... and I'll fix it myself."

We decided to study treatments for Prion's disease, including lethal familial insomnia.

Emerich declared before Pharma.

"I've been wondering how my clan got sick"

Whether you think about it or not, you didn't know why you would be cursed by the patron saint, the drug god, Emerich says bitterly.

"But now, I think I finally figured it out. After meeting you, completing the cure for this disease doesn't seem like homework from my patron saint, the drug god."

Emerich's determination was stiff, which can also be taken as a strength somewhere.

Pharma was surprised by his strength, but looks reluctantly at him. Ellen nodded softly to encourage her, too.

"Medicine God, I think you'll watch. I feel that way."

That's what Ellen says, sending a subtle gaze to Pharma. Pharma shrugged her shoulders, coughed around and encouraged Emerich.

"Okay. I won't treat you, let me fix it myself."

"Thank you! I'll do my best crazy though I die!

Pharma beat the fear and stood up for Emerich's courage.

"From today on, you can freely use what you have in this lab to research. There's also an Adeno-associated virus, so you can modify it."

"It's an honor! Please coach us."

(For me, that's homework I took over from my last life. Either Emerich or the competition)

Humans who jumped into the world of research willingly are tough, Pharma thinks.

So that Emerich, who tries to find a cure for his life, can achieve great results.

Farma renews her determination when it is her role to coach her to make it happen.

As an instructor, I intend to spare no effort in supporting research.

And Pharma herself was trying to explore systemic gene therapies that did not rely on the ability of the drug god.