Parallel World Pharmacy
Chapter 5: 19: Systemic Gene Therapy and Moving Forward to the Pharmaceutical Division
Pharma and the Empress returned to the palace after the arena and were invited to bathe because they would have sweated.
Although Pharma was relaxed to be guided to the bathroom for male guests, for some reason all the bath caregivers are appreciated for all the beautiful girls of her age, and Pharma thinks of the empress's plot.
"Dear Farma, I would like to wash your body. I'm sure you'll feel better."
"No, I will serve you. Wow, is this the holy print on your arm?
"Ah, Master Pharma, what a lovely man. Why don't you do something nice with me?
I tried to serve Pharma so that the beautiful girls wrapped around highly exposed costumes would compete, but I felt desperate.
"No, you know, I'll wash myself before. If it's your back, yes."
And, he was blocking sexual services by fronting.
(Don't let me find my daughter-in-law here, Your Majesty...)
"Whew!? Ah-ha, hey, stop... hi-ha."
Pharma had been tickled aside and the character had collapsed.
When the spiritually exhausted Pharma finally freed her from an hour of bathing, the Empress waited for Pharma as she let Juliana give her a massage. Salomon is beside him.
"Is that Your Majesty's offer? What about those girls?
The extra help was immense, Pharma resents. Mostly, even if they force you to make a pageant like this, you're just in trouble.
"Did those people do their job well? Did you get a good look at that?
The empress had completely turned into a matchmaker, not even an aunt, so the matchmaker, Farma, cares once and for all.
"In such a defenseless place, it doesn't have to be a good vibe."
Farma was angry, although the way he spoke might be disrespectful.
"Hmm, would you like some tea?"
The Empress, who finished Juliana's massage, invites Farma to take a seat at the Tea Party.
"So I have a problem with that..."
"Hmm, I'm not a man who can't react with that! Damn, it's not funny how you develop as a boy! Which is more confirmation..."
Salomon, who saw Pharma twisted in the empress's reverse sexual harassment, coughed up and sent out a helpship. Farma was rescued just about to be attacked by the Empress.
"Your Majesty. By the way, was Farma categorically opposed to the founding of Protestantism and its patron sainthood?"
"Hmm. That's tough."
The Empress has no words to say back.
Says Salomon was able to anticipate the outbreak of an accumulated cloud wrapping the arena and a huge divine power cloud. Pharma added that he didn't just disagree.
"Your Majesty's feelings are appreciated. However, it is unlikely to meet your expectations. The founding of Protestantism means treason and separation to the Holy Nation. If the Holy Nation orders neighbouring countries to crusade as a rebel nation, the peaceful Saint-Fluve Empire cannot remain as it is today. I thought we should look for a way to reconcile with the Holy Nation."
"That's the way Farma is, Your Majesty. He who thinks of his people more than the danger he poses to himself."
Salomon speaks for Pharma and tells the Empress. Juliana, too, grinned when she saw Pharma as relieved somewhere.
"If you are denied that you are not a patron saint, there is no treatment. It's the first time I've played with Pharma, but he's got extrahuman divine power, and the bottom of divine power doesn't seem to exist, and it's been a long time since I've learned something called fear in a struggle. I'd love to play every day if I could."
"I refuse. Earlier, I unintentionally hurt Your Majesty. Fortunately I was able to heal with divine power... but I don't know what will happen next"
Back from Holy Springs, Pharma was able to even repair damaged tissue by focusing on divine strength.
However, there is a sense that the power is out of control, and when you may slip your hand and launch an instant death attack, etc.
The developments that followed, I didn't even want to think about.
With a bomb that you may never know will go wild, Pharma is in a state of daily life on the loop.
"I thought I'd go to the Holy Land and let” gear "suck the extra divine power."
"Dear Farma. I don't know if that's a good idea."
Salomon, who heard the word, expressed the colour of his concern. The same goes for the Empress.
"What are you saying, isn't it the pot that the Holy Nation thinks? Is there a device that" keeps the world in gear "? Actually, it doesn't exist, it's just an excuse to attract a patron saint and take away his divine powers."
Juliana, who was listening to it, sandwiched her with a word.
"Wow, to my knowledge, a device called the gear of exists. However, thanks to Father Pharma's previous division of divine power, the gear will last two hundred years. It's not a matter of urgency."
Juliana is a former Privy Cleric who learns about the trends of the high priest Pius.
"Juliana and other pivotal clerics may be deceived. I don't suppose you witnessed that?
The Empress didn't even talk about ”gear of \37
Farma is noticed on the new side of the empress that her extravagant temperament is not all she normally looks at.
"Indeed, it does not seem to be visible in the human eye"
Juliana blurts her tone when she sees that there is no way to visualize the gear of .
Farma returns her words to the Empress as she follows Juliana.
"I know the Holy Nation is trying to abbreviate me, but I am stronger in divinity than before and I also have trouble living my daily life. I think it would calm you down if you consumed divine power on a large scale, but there is little place for that, and I don't use it, so it accumulates in my body."
Honestly, I wanted to dissipate once if I could dissipate.
"So it is beneficial for both sides to come directly into divine focus on the gear of that it lies beneath the Holy Nation"
Together with the Holy Nation crushing its purpose of targeting Pharma, it gives divine power to the gear of . Other than that, we are unlikely to be able to diminish divine power in a common sense way. It will always involve acts of sabotage.
It was also thought that the only way that divine power could be consumed in large numbers, a series of massive epidemic sanctuaries, might reduce divine power somewhat, but the epidemic sanctuary itself is a form of environmental destruction that kills microorganisms.
Even though there is no plague, I can't use it if I get nauseous.
(As a last resort, let go of divine power toward the end of the universe, but that would be a waste of divine power.)
So it consumes divine power in a meaningful way, and it is quick to use the gear of when it comes to it.
"First, I want to find out for myself what the gear of is"
"That's dangerous. For example, what if the device and its power were not to be concentrated from the outside, but to devour the patron saint and crush it? If you go, you're out of luck."
The empress shakes her head. Observe from afar, how dangerous. If so, do not approach, as Pharma was about to come in that stance, but the Empress did not allow Pharma to approach alone.
"Then I'll accompany the rest. Meet Pius at the same time. Let's schedule it."
(A meeting between the Empress and the Great Cleric... there's going to be a turmoil)
Farma predicted that it was not likely to be soothing.
The Empress offered to meet with the Holy Nation and, as a result of scheduling, the trip to the Holy Nation of Pharma was decided the following month.
Before going to the Holy Land, Pharma is concerned about something.
(I don't know what's in the Holy Nation, and I'd at least like to settle for gene therapy for the Emerich clan)
He has since been an animal model with hereditary diseases, and Pharma's gene therapy has been successful in several cases.
Faster appointments and finally move on to treating people.
Japan passes national review boards and so on to advance to clinical trials, but there is no such thing in the Saint-Fluve Empire.
So Farma showed the data to the empress and the samurai doctors, court pharmacists, and tried to get authorization.
Ellen flickered when she attached the promise of Elizabeth's first pre-ethics review meeting and was troubled by the cure that it could only be used for Pharma, and how she explained it to the other pharmacists and samurai doctors.
"Hey, maybe we should just use the treasure to administer it? Farma, your hands, too, but the treasure can see through the human body, can't it?
Pharma's cure, he mistakenly thought, could only be done by Pharma, but said anyone could do it with a treasure.
"Human beings may not have treasures, but they can't have them if they devise a way to hold them by wrapping them in inorganic objects. With that, we can penetrate the human body and administer medication all over the body, and not to anyone?
and Ellen explains. I thanked Ellen because it was an idea that Pharma couldn't think of.
"I can't come up with drugs like you, Farma, but if this helps, I'm glad."
Ellen seems to be good at figuring out a cure in combination with theology.
"It's going to clear the way, Ellen."
I made a presentation at your meeting, including Ellen's idea, and the samurai doctors and court pharmacists never questioned me, so I went through.
I just started explaining the CRISPR/Cas9 system and half of them may have already lost track of it.
But Claude and Bruno, as well as the doctors and pharmacists who were listening to Pharma classes at Imperial Medical University, praised them for understanding the system. At the end of your previous meeting, Claude throws a question to Pharma.
"May I use your medicine to treat patients in the future, too? How am I supposed to formulate my medication?
It was the first time Farma had received such an offer from a doctor.
The doctors and pharmacists present also nod in tune to Claude.
Court pharmacist Françoise de Savoie was one of them, but she expressed concern.
"Is it something we can handle? Medicines that work well can be dangerous if they are misformulated."
Françoise doesn't think he can easily get his hands on Pharma's new drug because of the different pharmaceutical system. Nor is Pharma going to leave the dispensation of modern medicines to the inexperienced and knowledgeable, regardless of the over-the-counter medicines handled by the Pharmacy Guild, which have no serious side effects. If that's the samurai, it's the court pharmacist.
"Right now, at Imperial Medical University, we're training experts who can handle new drugs. It will take several years for the first graduate to come out. But in that case..."
So Pharma taught us simple procedures for handling new drugs.
A few days after I was granted permission for gene therapy at your previous meeting, I finally got to work on the gene therapy for my second son, Oygen, who needs it urgently. The procedure should be performed in a pharmacy with a treatment room, not a university.
"Hello, thank you for today"
Emerich, the party's brother, brought his brother Oigen to the otherworldly pharmacy at the appointed time of Pharma.
"We're here with you, too ~"
There was a raging voice, and his sisters, similar to Lotte, followed him with straw.
Lotte, who went out to serve customers as usual, was introduced to them again by Pharma and was confused.
"Come on, Lady Pharma says there's blood connected to these people. What you mean..."
Lotte's mouth is pounding open.
"I mean, we're relatives. Nice to meet you."
My sisters shake hands with Lotte and rejoice face-to-face.
"But me, I'm a civilian! But!? How could you be related to a nobleman?
"Oh, that's a lot..."
Pharma explains the situation from the side to the side so that the conversation is not twisted.
Lotte was surprised to learn that he was descended from a former nobleman who lost his divine power and became a civilian.
"Ladies and gentlemen, what attribute of theology are you? By relatives, is it possible that I can use divine arts if I work hard too?
Lotte was excited, curious, but seemed fundamentally wrong, so my sister tells Lotte.
"All of our siblings' attributes are either water or wind. God is born with power, so if you don't have a divine vein, you can't, I'm sorry."
Lotte looks a little sorry and then regains her usual energy. She was a fast recovering daughter.
"Oh, right. I feel kind of strange. My name is Charlotte! May I ask your names?
Lotte without brothers and sisters seems to have suddenly seemed to have a brother or sister, smiling happily.
"I'm so glad to see our kin in such a distant exotic land by chance!
"Me too ~!"
(Uh, women, they all have similar voices)
A similar tone of voice sounds right inside the pharmacy.
Pharma also smiles at the fact that the lotte ingredient is three times less lively. When the story thrived and my voice was as high as an octave, Pharma couldn't tell who was talking from the way through.
They were talking in some seriousness, but when Pharma was listening,
"Next time, let's all go have some delicious treats."
"I found a very delicious Kgrov shop in Teito. Totally like it."
"What, where's the store? I care! It's my first ear!"
I was totally in the mood for sweet rigging.
(I knew it would happen...)
Farma gets to the point, thinking that, in a way, sweet lovers may be family blood.
"Now, please wait upstairs while you all talk. Let's go, Mr. Oygen."
"Best wishes, Doctor"
Leaving Emerich and their girls on the ground floor, Farma joins Ellen, taking Oigen into the upstairs treatment room.
"Come on, Mr. Oygen, fall asleep on that table"
"Please"
Oigen lies in bed, sweating cold. She seems nervous and hardened. Oigen was of some frail physique, an atmosphere that had not yet developed morbidity but was already ill.
Some people forget and are unaware of the "curse of the drug god" that sprinkles on the clan and the inescapable death in their daily lives, while others are haunted and spiritually distressed throughout four or six o'clock.
Oigen was like the latter.
(Mr. Oygen, I hope you're not bothered about your illness when it's fully healed and you're feeling better)
"Then make your feelings easier. You have to hurt your eyes with the light of divine art, so I'll blindfold you."
I laid on my back to Oigen with Ellen wearing an eye mask with a proper explanation.
"By the way, you haven't had any symptoms of insomnia yet, have you?
Pharma confirms the symptoms before treatment.
"Yes, I'm not out yet, I sleep well. My body feels a little burnt... Is this an early symptom?
"Perhaps so. But even if it's not, I've never been over to start treatment early. If it doesn't develop, we need to minimize neuronal destruction."
"Right, I'm still glad you did it today"
Oigen seemed ready.
"I don't think there will be any pain in the upcoming procedure, but please tell me if you feel uncomfortable, because I will stop immediately"
Pharma, who finished washing his hands, tells Oigen.
"Please"
Pharma began by examining Oigen's body using the eye.
His whole body, which has already developed lethal familial insomnia, looks slightly red.
Red light was meant to be an untreatable disease.
(Wow, it's red. You couldn't see the light before, but you're progressing fast. I need to get better soon)
If left alone, there will be one more year where Oigen's death will be inevitable.
And after any further progress and destruction of the nerve cells, we will have to take the difficult step of regenerating the nerve cells.
Still, Oigen's nerve cells are safe, and he hasn't gotten insomniac either.
It was the perfect time.
(Can't delay even a day, the medicine is ready. cure before it develops. Today's the day!
Pharma was trying to overcome the impossible with an untouched hand on Earth.
The synergy between cheat abilities and Earth's medicine has made systemic gene therapy possible.
When Pharma shakes off her hesitations, she writes the compartment in plaid form, marking the street from above Oigen's clothes.
To know exactly where the dose was given to your body.
"It's a very unusual divine art, isn't it? It's ticklish."
You tickled the marking, Oigen twisting your body.
"Oh, please don't move. 'Cause it'll be over soon."
Either because Ellen fixed Oigen's body, or Oigen's heart rate rises. Do not let Oigen know what Pharma and the others are doing.
Because he doesn't know the details of "divine art”. I should have explained the treatment and obtained the patient's consent, but there is no way I can say that it is a treatment that uses Pharma's hands to be transparent, etc., and it stays with the explanation that it is such a divine art.
However, all the side effects, risks and possible sequelae generated by the divine art were explained.
"Farma, you've prepared your medicine."
"Thanks"
Ask Ellen to hand over an anti-prion antibody with a label substance that calculates and prepares a theoretical dose, as well as CRISPR/Cas9, a modified sequence, and a set of other mixed solutions.
Pharma softly administered labeled antibodies and gene therapeutics in a method of administration that utilized the properties of his hands that permeated the human body, which he unquestionably named "permeable administration".
"It's going well. Block five, that's fine. Next number six, the dose isn't wrong."
Under Ellen's complete guide, Pharma continues to work mechanically. Safe, complete with systemic administration.
"All compartments are ready for administration."
"Okay, I'm going to the next step."
("Erase 5-carboxyfluoroseine")
Pharma quickly put his right hand on Oigen and silently activated his ability to erase it.
Eliminating antibodies that recognize and bind prion proteins, labeled fluorescent materials that are not present in the human body, can also destroy the binding sites to prion proteins together, both normal and abnormal.
Proteins that have been partially destroyed break down quickly.
"This should have destroyed all the prion proteins. And then there's the gene therapy."
"The simultaneously administered gene therapy system is already starting to work, isn't it?
Ellen confirms.
"Yes, this is where we're going."
The genes in Oigen's somatic cells will have been correctly rewritten with CRISPR/Cas9 and the sequence for modification.
By this treatment, the prion proteins that will henceforth be produced in all cells of Oigen will be of normal type only.
The germ cells have also been rewritten, so we don't have to worry about the inheritance of the genetic disease to our offspring.
The same treatment several times over the day ensures that cells of repellence are not present.
Theoretically possible. And it has been successful so far in both animal experiments and without serious side effects.
And then, whether or not it works for human patients. That's everything.
"Come on, I guess it worked"
Pharma took a deep breath, relaxed her stiff shoulders and took a breath before activating the diagnostic eye.
The red light that was wrapping Oigen's body was completely disappearing.
(First, is it a success?)
Pharma is touched by his overcoming of the red light, which means he is incurable.
"What do you say, Mr. Farma?
To Ellen, who asks roughly, Pharma grinned as she made a mare at her fingertips.
Ellen was happy to be with me.
I wake up Oigen, where Pharma is sleeping, trying to share the joy.
"It's over, Mr. Oygen."
"Huh?! Already!?"
Oigen jumps out of bed.
"At last, I feel good..."
"Please wake up slowly, you can stand. Let's go to your family."
Pharma leads Oigen to the first floor of the pharmacy. Emmerich was waiting under the spiral stairs.
"How about you. Nothing?
"It was nothing. I've been asleep, comfortable, neat as a possession."
Oigen had a bright, invisible look, like he was reborn.
"Professor! What happened to my brother..."
Emerich asks Pharma nervously.
Pharma lowers the sleeves of her white coat and nods as she hides the meds divine marks on her arms.
"I think you're succeeding. Not for today. And then let's keep an eye on the progress."
"Thank you! Thank you! Thank you!
Emerich was as happy as he was about his brother's recovery.
"Dear Farma! There was a patient. They brought this."
After seeing them go home, Lotte hands Farma an envelope marked with a wax.
"I finished my practice today, okay. It's out of time, but I'll check it out."
Pharma made a bounced voice after revealing inside the envelope.
"Right, here we come!
"What?"
Ellen takes it. It was the first time that Pharma founded a different world pharmacy.
It was written:
Patient's name, age, address, date of issue, issuer, aristocrat (in which case attribute and patron saint) · by civilian,
And prescription.
"It's prescription. From the doctor."
The prescribed physician is Claude de Chauliac.
Claude, an Imperial Pharmaceutical University and Medical School professor and chief samurai, wrote a prescription to an out-of-hospital pharmacy, a different world pharmacy.
After surgery for trauma, he had prescribed cefcapene pivoxil hydrochloride for modern medicines handled by Pharma to prevent postoperative infections. Calculated from body weight, doses are also specified and methods of administration are described.
When Claude said he wanted to handle Pharma's medicine, Pharma replied, "Write me a prescription." The style seems to have been conceived by Claude, but there are a few things in common with Japanese pharmacies.
Farma sits in the waiting seat to meet the Count who was waiting and follows the procedure to see if the formula is correct.
"Today, why did you see Dr. Claude?
"Oh, yesterday, you did a good job here. I came all the way here because I told him to take the pills and take the letters directly here."
The Count cut his fingertips so deep with a knife that he called Claude, his primary care physician.
Pharma used the diagnostic eye and was surprised that the wound after treatment was clean and not purulent.
The letter accompanying the prescription says that he listened to Farma's textbooks and lectures and changed the way he treated them.
"What, the chief samurai has been designating drugs? Why don't you send me a patient, Farma, and you'll see him this way? Pallet, you always do that."
Ellen looks surprised.
"Sending patients doesn't mean the same thing as sending prescriptions, Ellen."
Practice and prescribing is the doctor's job, auditing and dispensing is the pharmacist's job.
From the feeling that Pharma was a pharmacist in his previous life, he wanted to avoid, if possible, practicing pharmacists, that is, seeing patients and prescribing them independently.
(You think it's the original pharmacy where doctors practice and prescriptions come from outside. Pharmaceutical division is the principle)
In Japan, the pharmacist audits the medicine prescribed by the doctor and asks the doctor if this medicine is okay if there is any doubt.
Another pharmacist who dispenses and is not the dispensed pharmacist if there is no doubt about the prescription will make the final audit.
Pharma thinks that a two-step audit will be conducted and the medication will be used appropriately by the patient, and that's what the pharmacy wants.
"Even Dr. Claude's prescribed cefcapene pivoxyl hydrochloride isn't bad, but in this case I wonder if cefachlor would be more efficiently absorbed by the human body"
Pharma thinks that the consideration of such a fine drug choice will soon be over.
Claude's prescription made Pharma feel the urge for modern medicine to take root one by one in the Saint-Fluve Empire City.
"Little by little, you're changing. And the people of this world..."
Ellen sent something to Pharma, who shrugged emotionally, and took out the beaker and drug wrapper she had served for Pharma.
Lotte sings a nose song and folds a shortage of medicine bags, and Cedric calculates the pharmacy's sales and puts them in the safe. The part-time pharmacists are nagging to organize the medical records and clean the dispensing table as they chat so much after business hours.
And Pharma spelled out the prescription she came for in a brand new file and began dispensing her last patient today with fresh feelings.
I realised that it was myself who changed...