Riyu's Back File 2011

For Miyazaki Sosuke, he must rely on teamwork, with the help of Yoshida Kenichiro, Pascal Soriot and others to help him manage the company.Technology and people are the two most fundamental factors driving business development.

The success of an enterprise will be affected by globalization, which is the reason at the macro level.In addition, certain local factors are also very important, such as management capabilities and management methods, which will have a significant effect on the company.

Therefore, business is a very grand thing, and the prospects are unpredictable.It's not that you can succeed if you make a plan.No matter when, nothing is done. Entrepreneurs need a lifetime of continuous learning. This is true for Miyazaki Sosuke, Pascal Soriot and others.

For example, Pascal Soriot, the CEO of Ben Life Pharmaceutical Group, is learning how to communicate with Ben's executives.

The development of this pharmaceutical company is different from the European and American companies that Pascal Soriot worked for, both in terms of R&D ideas and corporate management methods, and has many unique business characteristics.

For example, the current main R&D project of the Biopharmaceutical Group, drug development in the direction of tumor immunity, is based on the basic research of the local scientific research institutes, coupled with the company’s own product development, which is different from the R&D methods of many European and American companies .

After nearly a hundred years of development, this research and development model, whether it is basic pharmacy scientific research, later product development and marketing, and global sales expansion, yes, the development of the pharmaceutical system of the Life Group has been very mature.

Nowadays, as long as two medium-sized pharmaceutical companies have absorbed Wild Pharmaceutical and Shiono Yoshihide, plus some large-scale pharmaceutical companies acquired in the previous period, the current development and marketing of the life group is not uncommon, and nearly 30 kinds of drugs have been listed. The product.

But for Pascal Soliot, a rich product line does not mean huge profits. The first problem he faces is that among the complex product lines, he chooses the one with the highest chance of success and concentrates resources on launching several doors. Pharmaceuticals allow companies to reap high profits.

"How is the progress of the nivolumab project?" Pascal Soriot interrupted the management's chaotic discussion and asked loudly.

"The third phase has already begun, and the early performance is very good. If everything goes well, we can apply to the regulatory authorities next year, and we will be able to spend on this in 14 years at the latest." Senior Vice President in charge of drug development, Yoshino Hara The CEO of the pharmacy handed Mogong and turned over the file and replied.

Nivolumab, English name Nivolumab, also known as "O drug", is a fully human monoclonal antibody that acts as a PD-1 blocker and can bind to PD-1 and relieve the PD-1 pathway from affecting T cells. Inhibition, thereby exerting a series of anti-tumor effects.

Simply put, this is an anti-cancer drug, and it is also the main project that Wild Pharmaceutical has been promoting before.However, after the company was merged, Teyoki became the direct person in charge of the project.

"How effective is it? Is the market potential comparable to ipilimumab?" Pascal Soriot continued to ask.Ipilimumab is one of the main products launched by Wild Pharmaceutical. After being approved by the FDA in March 2011, it has been gradually marketed all over the world. After one year of market feedback, the overall sales have been flat and can remain at ten. The scale of about 100 million US dollars.Now this drug has also become a good first-line listed drug under this life.

"If all goes well, the market feedback of nivolumab should be better than ipilimumab." Handyomu Gong is confident about the projects he is responsible for. This is also based on the fact that the drug has achieved very good results in the preliminary trials of the drug. Effect.He is sure that Nivolumab can achieve better results, but he is not sure how good it is.

"In this case, do we still need BMS? I think we can give up working with them." Pascal Soriot knocked on the table and asked a question.

BMS is a partner of Wild Pharma, an American pharmaceutical company. Nivolumab, Ipilimumab and other drugs are all drugs developed by Wild Pharma and the other side.In the marketing of new drugs, Wild Pharmaceutical also shares the global market with each other. The two have consistently divided the global market after the drug is on the market into this region and other regions.

Wild Pharmaceutical is responsible for the market sales in this region, while BMS is responsible for the actual market sales in the United States, Europe and China.Perhaps at the beginning, Wild Pharmaceutical was stuck in not having enough channels to develop markets other than the original one, and could only hand over to the partner BMS, but in Pascal Soliot's view, it is no different from throwing money.

"I also think that the cooperation with BMS can come to an end." Teyoki raised the glasses between his nose and said with a smile.

For him, a partner like BMS that has a close relationship with Wild Pharmaceutical, one less counts as one.Although the management of Ye Pharmaceutical was waved away by Miyazaki Sosuke for resisting the "Master of the King", the struggle between the Ye and Shiono within the Life Group is still continuing.

"Then the development of foreign markets is up to you, Yumu will be too sang!" After Pascal Soriot became the CEO, the board of directors gave him a major task to establish a global sales network for the Life Group.

"No problem, leave it to me." Yumu Jiangtai, the senior vice president in charge of marketing, said confidently.

Weida's more than ten years of work experience has made him an excellent marketing master.This is also one of the main reasons why Miyazaki Sosuke values ​​him so much.

###Chapter One Hundred and Forty-Eight Features of Murakami###

Not long after Tanaka Minami and Maeda Atsuko came to Kiyosumi Shirakawa, Miyazaki Sosuke also came to this Shitamachi in Tokyo.Compared with the prosperous business districts such as Ginza and Shinjuku, Shitamachi is more of an old town.Coupled with the emergence of cafes and grocery stores, Kiyosumi Shirakawa has become a new gathering place for young people in Tokyo.

"I often come here for a walk, and I seem to find that I will be much younger." Haruki Murakami, wearing a brown polo shirt, walked with Aosuke Miyazaki on the path of the Kiyosumi Garden.

The Kiyosumi courtyard of Shirasumi subway station staff was originally the residence of wealthy merchants in the Edo period. It was later built by the founders of the Mitsubishi Foundation and has now become a "traveling forest spring courtyard" with spring water, rockery, and dry landscape. "It has also become a place where Murakami takes a daily walk.

Miyazaki Sosuke looked at the trees outside the trail, looking from near to far, small bridges, flowing water, trees and rocks blending together, not only can make people feel the fun of Japanese gardens, but also make people feel calm.In Kiyosumi Courtyard, there are few people and quiet, but it is morning again, and there are no people in sight. This also provides a good environment for conversation between Miyazaki Sosuke and Murakami.

"Does Miyazaki-san like my work?" Halfway through, Haruki Murakami found a stone chair and sat down, and Miyazaki Aosuke stopped with him.

"No one should dislike Murakami's work!" Miyazaki Sosuke couldn't help laughing when he heard Murakami's question.

This great writer born in Kyoto has been creating classic works one after another since the release of his first work in 1979. He has left his own uniqueness in the history of Japanese literature and even the history of world literature. Traces of neglect.

"So, do you want to adapt my novel because you like it?" Haruki Murakami's answer to Miyazaki Sosuke was not surprising.As the best-selling author in contemporary Japan, he is confident that Miyazaki Sosuke wants to participate in this project because he likes his work.

"Mr. Murakami's work, I like a lot, but I really say that there is one that I particularly like, I probably haven't yet." Speaking of Murakami's work, Miyazaki Sosuke's interest also came.

"Oh? Why do you say that?" When Miyazaki Sosuke commented on the work, Haruki Murakami also became interested.

As a prolific writer, Haruki Murakami has published dozens of long and short stories, plus a large number of essays, travel literature, reportage, and co-authored works, which are quite a few.

However, it was the first time that Haruki Murakami heard of this evaluation.Of course, this is also related to Murakami's own dislike of hearing too many comments from others.

"When I read it before, I would think in my mind, which short story is this adapted from yours? After thinking about it for a long time, I finally found that the original is a derivative work. There are derivative works, both.

Later, I discovered that when you are creating, there will always be an idea of ​​"Well, this story can be placed here!"

Was stuffed inside; the episode of going back to my hometown to see the sea appeared in your early collection, and the first half of the emotional story appeared in and inside.

The fun of "guessing the puzzle" has always been an essential entertainment activity when I read your work.But it is this kind of fun that prevents me from really falling in love with your work. Although I like it very much, it is the feeling of separation that always makes me fall in love with it, so close."

As a senior book fan of Murakami Haruki, Miyazaki Sosuke has read almost all of his works and is very familiar with Murakami's writing style.

Miyazaki Sosuke's words also made Murakami couldn't help but laugh. After listening, he patted his thigh in the quiet courtyard and laughed.Because Miyazaki Sosuke did vividly portray the psychological activities of Murakami Haruki when he was creating works.

When creating the work, Haruki Murakami himself really just wrote and thought, "Ah, this story can be placed here, this short story can be changed to a long story."

Haruki Murakami is good at tracing the details of atmosphere in a few words. He will introduce people into reality or lead people into the dark world on the other side. He will let you read a book and look up at your surroundings. Everything seems clearer; this is his short story Strengths.

But if it is stretched into a long story, it is more or less likely to have a sense of uneven texture; therefore, his novels have many fascinating details of the chapter, but they may not be able to make people repeat it all at once from start to finish.

The fragmentation of the later story; one line in the two-line narrative is much more exciting than the other; the same is true-it always makes people feel, "If this is broken into a short story, will it look better?

"Then you want the right of adaptation because it is complete in your eyes?" After a long time, Haruki Murakami finished laughing and began to introduce the topic.

"No, if I get the right to adapt, I will make a substantial adaptation, and even in a sense, there is not much difference between me and creating a new work again, even the character setting will be different. ."

Miyazaki Sosuke’s words surprised Murakami, but they were true.The original work of Haruki Murakami is only a few thousand words, so it is not complete.If you are a little shameless, you can say that it is your own original after being adapted into a movie. After all, after filling in so much content, many details will not affect the quality of the movie.

"If that's the case, why should you come to me? Japanese audiences will not contribute an extra movie ticket just because Haruki Murakami is added to the movie."

When Haruki Murakami said this, he couldn't help laughing or crying.In today's video age, literature and film are very close, especially best-selling literary works. Their adaptation rights are the prey pursued by film companies every year.Literature and film are interdependent.

However, as the most important writer in contemporary Japanese literature, Haruki Murakami's works have not been filmed.

The main reason is that in the early days, Haruki Murakami took the attitude of playing tickets and gave the right to adapt his own works to college or high school alumni. These people's experimental film works also made Murakami "wake up".

Regardless of whether Haruki Murakami's adaptations are commercial or art films, the evaluation is good or bad, they all have two characteristics in common.

First, most of the adapted films did not fully embody the spirit of Haruki Murakami’s original work; second, the box office of the adapted films was not very high, and unlike Miyazaki Sosuke’s big sales, Japanese audiences did not eat it. A bonus to the name Haruki Murakami.

Simply put, the film adaptations of these works have failed!

### One hundred forty-nine chapter signature###

Of course, the reasons for the failure of the adaptation of the film are not entirely the responsibility of the director and producer.One of the key factors is that Murakami's text is not suitable for adaptation into a movie.In Murakami's works, there are horse-like imaginations, complex and delicate psychological feelings, and a large number of indescribable detailed descriptions, all of which increase the difficulty of film adaptation.

In addition, a major feature of Murakami is the discussion and borrowing of other art forms, especially Western music, literature, and movies. Such complex genus is also difficult to present through influence.

It is precisely because of the failure of the early playing ticket era that Murakami has not handed over the right to adapt any of his works for 16 years from 1988 to 2004. He seems to have Start thinking seriously, it's time to take the video problem of my work seriously.