Rule system

Through the verification of the Law of Cause, Zhao Yi has determined his own analysis. The detection mechanism in the immune response process is indeed based on protein sorting the 'detection password'.

He announced the result of inference in public, but it was not sure that it must be.

In many experimental studies, imagination and judgment are important, and it is not necessarily verified by judgment, because many judgments have no way to verify.

That's it now.

It is impossible to do experimental verification before it is determined to get further results.

So Zhao Yi directly arranged the next work: doing protein exclusion research.

Because the eleven types of protein that may be associated with immune exclusion reactions is a kind of protein may not be directly associated.

This is a certain conclusion.

They must screen out that they are related to eliminate those who are not related.

The research of protein exclusion is more complicated. You can understand the 11 associated proteins in this way. They are proteins distributed on the human cell membrane.

Some proteins will participate in the detection of immune response, and some protein has other functions.

Then if you want to detect which protein and immune response are directly associated, you must do the extraction experiment one by one, and then inject the extracted single protein into the target body.

The goal, the goal of extracting protein must be the same source.

In fact, the best choice is the human body, not certain organs, parts, or blood, but now they have not yet applied for volunteers to participate in experiments, they can only perform auxiliary research in other ways.

Then the process will become more complicated.

For each protein, many experiments must be performed. After getting the data, detailed analysis is required, and a lot of comparison is made to determine the correlation of immune response.

It is also very difficult to analyze the correlation, because there is no determination to do it, and the data can only be taken out for analysis.

For this job, the laboratory is still confident.

Because Zhao Yi is in.

Zhao Yi is the top mathematician. He is very sensitive to numbers and can always see the key.

Therefore, the people in the laboratory are very confident, and the entire laboratory also devoted himself to the study of protein exclusion, including several researchers, a dozen associate researchers, and even a dozen assistant researchers.

The laboratory was busy doing a group, experiments everywhere, and reporting everywhere.

Zhao Yi sat in the central office and kept watching the experimental design and results sent by it. Such a busy state lasted for about a week before finally getting a positive result.

The laboratory held a summary meeting.

Zhao Yi announced, "Through a series of experiments and analysis, we have determined that the seven proteins are directly related to the immune detection. The other four proteins are not related."

He passed a report to everyone and pointed out the comparison results of the data in the experiment in detail.

Without this clear report, in the face of a lot of experiments and data, anyone will feel a headache, but through the data comparison on the report, they can clearly see that the results are divided into two data situations. The data of the seven protein is similar, which is one case, and the other four protein data is another situation.

This is clearly explained that the seven proteins and immune detection are directly related to the list.

"According to the conclusion obtained from the previous experiment, we can infer the key to immune detection is the arrangement of these seven proteins."

Zhao Yi drew a picture on the whiteboard with a human cell membrane marked on the picture. A tentacle was grown on the cell membrane. The tentacles were composed of a long string of seven circles. He explained, "This is the key to immune detection."

"People with different blood types, the blood type antigen on the red blood cells is different, and the blood type antigen refers to the protein on the surface of the cell membrane."

"We all know that the difference in blood type antigen refers to the different protein expression. For example, the blood of type A and B, the molecular keys at the end of the antigen protein are slightly different."

"And people of the same blood type are consistent with antigen protein. When the antigen protein is consistent, the immune detection can cross the first stage. This is the first step."

"Even people of the same blood type will have a certain immune rejection response. Why? It is because of immune testing, there is a second step, and it is also the most critical step: protein sequence detection."

"The seven proteins we found are directly related to immune detection. Different people will have different protein sorting combinations."

"Detecting the contact of the cells will have corresponding sort detection. Testing different protein sorting will trigger the immune response."

Zhao Yi said a bit, giving everyone the time for digestion information, and then continued, "Seven protein may have 5,040 sorting."

"In other words, the same blood type will have 5,040 different immune characteristics."

"This is the conclusions that we summarize the analysis through experimental data. It is just a possibility, but we can use this to design verification experiments."

"For example, find someone with the same immune characteristics."

"Huhhhhhhhhhhhhhhhhhh

After Zhao Yi said the last sentence, it suddenly aroused heated discussion in the conference room.

The medical community is recognized as a person with the same immune characteristics. In other words, everyone's body has an immune rejection response to the cells of others.

This conclusion is already recognized.

But if you think about it carefully, there seems to be enough institutions to conduct sufficient number of experiments to verify.

This is also normal.

Generally, contact with other people's cells is completed by blood transfusion and organ transplantation. The blood transfusion immune rejection of the same blood type is not great. Even if there is an immune rejection response, it will not know without detailed testing.

The number of organ transplants is even less. Even if the subsequent immune exclusion response is very small, most of them will be attributed to the effect of the drug, or the patient's recovery ability is strong.

In addition, Zhao Yi said the probability of the same immune characteristics of the same immune characteristics is also very small.

The same blood type, 5,000,40 immune characteristics.

It must be a very huge job to conduct detailed screening verification.

When the conference room was quiet, Zhang Wei asked, "How to make such a huge screening experiment, we must cooperate with the hospital to get enough blood samples, and enough data."

Li Ming shook his head, "It's not enough to be a hospital. Because through the blood, we cannot verify this conclusion. We must also cooperate with other medicine and experimental institutions."

Others have also expressed their opinions.

It is easy to verify whether there is an immune exclusion response, but it is very difficult to get enough sample data, and it is difficult to perform experiments in targeted.

This is a simple and huge job.

The same blood type, 5,000,40 immune characteristics, want to find people who have the same immune characteristics, do thousands of experiments, have bad luck, and even tens of thousands of experiments. Samples and materials needed. And the workload of the experiment is definitely very large.

Zhao Yi nodded, "I will say that let other experimental idlers also cooperate with it. In addition, I will apply for research and development funds to strive to get more funds."

"This kind of research is international, and it is impossible for all laboratories to contribute."

"Also, you can publish the results first-"

Zhao Yi's last sentence was a bit suddenly, but his meaning was clear. After publishing the results, other institutions may be verified.

This kind of verification experiment is okay who do it. Some other institutions help verify, and they do not need to take timely and laborious to verify.

That was meaningless at all.

After the meeting is over, the people in the laboratory are talking about the relevant conclusions. Each of them knows that the conclusion is the correct representative-

This will be the result of the Nobel Prize in Medicine.

Intersection

Zhao Yi is very sure about the results of the experiment, so there will be direct results of confidence. As for verification and the like, it can be carried out slowly.

If other agencies can help verify, it is better.

At the same time, the mechanism of human immune testing is that the improvement of the human immune process mechanism is also very important for future treatment and drug development.

This study is put into clinical application and drug research and development, and there are many directions to think about.

After determining the publication of the research papers, Zhao Yi went to the genetic laboratory and found the main researcher Zhang Ning. Zhang Ning has always worked in the genetic laboratory. He has made a lot of progress in research.

Because of the progress of research, Zhang Ning's work became busy.

After Zhao Yi found Zhang Ning, he directly explained the intention. "I hope that your laboratory can analyze from our conclusions and enrich the association of HLA genetic systems and outer cellular proteins."

He talked about the experimental conclusion in detail next.

Zhang Ning has always worked in the genetic laboratory and did not participate in the research of Zhao Yi's laboratory. She knew that the laboratory was very busy, but I did not expect such an important conclusion at all. "Are you sure? Zhao Zhao? Zhao? Academician? Is this conclusion verified? "

"No, but I'm sure." Zhao Yi talked about some data content and said that he was ready to publish the results.

Zhang Ning nodded and said seriously, "If your research is correct, it is definitely very amazing, which is very important for enriching the connection of genetic and cells."

"However, this is not to let me work, but to give me the results."

She said with a bitter smile.

Genetic experts do genetic research, and naturally they hope to make breakthroughs in genetic research.

If Zhao Yi said that the conclusion is correct, then you can directly connect the HLA gene system and cytosoma, which can analyze the immune detection from the gene and molecular level. Isn't it equivalent to putting the results in front of it?

Zhao Yi said without care, "As long as we have published the results, there will definitely be a corresponding laboratory for research." His meaning is to give them to others, and their research conclusions are Requires the research support at the genetic level.

The HLA gene system that the two people call is the main compatibility of human beings. Zhu Hexuan. It is the most richer genetic system of human polymorphism. It has determined that it is positioned in the 6P21.31 area of ​​the 6th chromosome short arm. Then, then, then

The HLA system consisting of a series of close chain genetic sites constitutes the "ID card" of human biology.

The medical community believes that each individual's immune activity cells use HLA as the identification of "themselves" and "non -self" symbols, so as to eliminate "non -self" by immune response and maintain the integrity of individuals.

In other words, the HLA gene system controls the decision gene of the protein sequence of immune detection.

If you can get the conclusion support of the HLA gene system research, you can prove the results of the protein sequence of immune detection. Even if you have not found people with the same immune characteristics for the time being, they have high persuasion.

Zhao Yi and Zhang Ning talked about the research issues, and also cared about Zhang Ning's project, but he quickly discovered what Zhang Ning could not say anything, because Zhang Ning did all genetic -related research, improve the human gene The library is just one aspect, it is still understandable, and the others are more complicated.

Later, Zhao Yi simply stopped talking.

After walking out of the genetic laboratory, Zhao Yi recalled that he found that he had underestimated science. He originally thought he was already 'omnipotent'. Even if he had not done research, he would definitely understand some.

Now he finds that the scope of science is infinitely vast. Medical research alone contains a large amount of knowledge. Neurology, genetics, immune studies, etc., there are only many theoretical research. In a brand -new field, he still and and with It was the same at first, and it seemed to understand something. In fact, it involved the profound content, or I still didn't understand anything.

"Industry specializing in surgery!"

"I can't scientifically run it myself-" Zhao Yi laughed at himself, and immediately felt that the decision to establish a genetic laboratory was extremely wise.

He went home leisurely.

In the evening, Yixing held an interesting news at the company's video conference.

Professor Bai Jianwu of the Microbiology Laboratory applied to participate in the research work of microbial vitamins of the moon base, and also passed the initial physical test.

"Professor Bai?"

"It's really amazing!" Zhao Yi said with sigh.

Although the age of the lunar base card is fifty years old, in fact, it is not easy for people over 45 years to pass physical testing.

First of all, without any basic disease, and passing dizziness, more than 60 % of people can be brushed.

Few people who have been studying for a long time are very good, and some foundations are common. For example, hypertension is common.

Young people are relatively good, even if they are a little obese, which causes a slightly higher blood pressure and can be reduced by losing weight.

After the age of forty -five, it is difficult to cure high blood pressure, and heart problems will occur.

In addition, the dizziness test is definitely a critical strike for older people.

Bai Jianwu can be said to be very remarkable through physical testing. His research and development experience is very rich, and it is really suitable for work to work in the moon.

Zhao Yi thought about raising his head and looked at the Yuanyue outside the window. He couldn't help thinking of Li Renzhen.

Now Li Renzhang is on it, and he is coming back to calculate the time, right?