Science and Technology Library

Chapter 467 Good News Is Not So Good

Hughes Institute of Medical Research, here is one of the most famous non-profit medical research institutes in the United States. With the global bioterrorism outbreak, under the coordination of WHO, the Hughes Institute of Medical Research has become an'angel team' to tackle VFV virus special effects Research institute.

Yau wanted to lead a few members of the team towards the meeting room.

Qiu thinks that there is a report in his hand about the research of VFV antibody, but everyone's faces are not too happy.

The antibody in the patient's serum or body fluids is the most commonly used method to treat viral infections.During the research during this period, their team found that the antibodies in the patient's serum were too weak to eliminate the VFV virus.

And they can't find patients in the recovery period. The VFV virus is too toxic, and the antibodies produced by the human body's immune system cannot'kill' the virus.

This has led to their research on specific medicines to be unable to do anything.

After discussion, the team decided to use animal immune serum to try and find 8 animals to experiment with the virus, but soon discovered that even the immunized bovine serum has no obvious effect on the treatment of VFV.

During this time, I have been experimenting every day and tried hundreds of possible ways.

After trying all the possible conjectures they discussed, they finally found that monoclonal antibodies have the greatest chance of success.

In order to speed up the research, the 72-person team was divided into eight groups, four groups were responsible for finding other therapeutic drugs, and the remaining four groups were responsible for testing the 16 kinds of monoclonal antibodies studied. The team led by Yau wanted to be one of them.

During the test, all four groups of people used 1000 times the LD50 (half lethal dose) to infect experimental mice.

Within 24 hours after exposure, mice were injected with monoclonal antibodies. Of the 16 monoclonal antibodies in the four groups, 11 were effective; at 48 hours, 5 antibodies were still effective; 72 hours, only two antibodies remained effective.

It is an antibody studied by the first group he led, and an antibody studied by the third group led by British medical scientist Judson.

After finding two of these antibodies, they began to experiment with rabbits. After 24 hours, both antibodies were effective. After 48 hours, the ability of monoclonal antibodies began to show obvious differences. Many of them lost their activity. Getting weaker.

The incubation period of the VFV virus is far longer than this time. Such antibodies cannot be used for treatment at all, and research has once again come to a standstill.

Finally, after everyone’s discussion, it was decided to adopt the “cocktail” method used in the research of EBOR specific drugs, using a mixture of 4 monoclonal antibodies with the best effect, and using a virus that can produce human interferon as an adjuvant for the “cocktail” antibody. , So that the "cocktail" can still function after 72 hours of exposure.

And the "cocktail" medicine was named AG72 by them.

And now, the results of the AG72 test are in the hands of Qiu Xiang.

Looking at the report in his hand, he couldn't be happy, because the result was different from what they thought.

When Qiu Xiang and Judson and the others entered the meeting room, they felt dozens of eyes falling on them.Many researchers on the field looked bad.Since the formation of the 72-person team, their research has made some progress, but the progress has not been much. Now the hope is all in the reports in the hands of Qiu Xiang and Judson.

"Come on." Yau wanted to pass the report in his hand to Judson.

"You come." Judson shook his head without reaching out to take it.

Qiu Xiang nodded helplessly, and when everyone sat down, he asked his assistant to send the report in his hand to every researcher on the field, and walked to the podium by himself.

"The monoclonal antibody test results came out, which is different from our predicted results. We tested the effect of AG72 with two rhesus monkeys. On the fourth day of infection, the monkeys developed symptoms and according to the plan, they were injected with AG72. Unfortunately, the virus in the monkey has not disappeared, and VFV has not been cured." Qiu thought, his voice was heavy.

There was a sigh in the conference room, and many experts shook their heads and frowned.

Monoclonal antibodies are the most promising direction for success in a short period of time. If monoclonal antibodies fail, the emergence of specific drugs will take longer.

Now the number of people infected with the VFV virus worldwide has reached more than 26,000, and this number is refreshing every day, and the death toll has soared to 2,378. There is no cure for the time being.If the treatment drugs are not available, it means that the number of deaths will increase.

"But there is good news that is not too good."

Everyone immediately cheered up, pricked their ears and waited for the answer that Qiu thought.

"The rhesus monkeys injected with AG72 did not deteriorate further within a week. AG72 could not cure the VFV condition, but it could inhibit the metabolism of VFV and control the further deterioration of the condition. This result can give the condition more treatment time. ."

Many people on the court applauded excitedly and wept with joy. At this time, any little good news is exciting good news.

The'angel team' made a breakthrough in the VFV virus specific medicine, and successfully developed a monoclonal antibody drug that inhibits the deterioration of VFV.

When the news was released, it spread to every corner of the world as if mad, arousing excitement among the people.

Now is the most serious period of the VFV virus. It is in a time of global panic, and the biological virus has almost reached the critical point of completely out of control.The good news came out of the 72-member team at this time, which is undoubtedly the most exciting time.

The victory of this war against biology has already dawned.

And when the outside world cheered for the results of the 72-person group, the same happy event happened in another corner.

Jianghe Institute of Microbiology Medicine.

Xu Minsheng had a rare smile on his face.

After the merger of Jangho and Lanhong Pharmaceutical by the Marchant Group, they were reorganized into Jangho Pharmaceutical. He became one of the team leaders of Jangho Pharmaceutical's pharmaceutical development, responsible for the development of tumor vaccines.

The current headquarters of Jangho Pharmaceutical is the main microbiological research institute of Haixing Company, and Haixing Company’s main medicines are developed from here.

Some time ago, Chen Mo contacted them, told them a research direction, and also gave them some information so that their research team can produce drugs related to the information. The drugs may reduce the activity of the VFV virus and be helpful for the treatment of VFV.

Now is the most terrifying time when the VFV virus is raging. Under Chen Mo's order, the entire research institute team immediately convened personnel to start the drug development.

The team concentrated the strength of the elite personnel of the entire institute, thoroughly studied the information given by Chen Mo, worked in shifts, and finally made progress.

During the period, he contacted Chen Mo several times and asked some questions about the research direction. After several major breakthroughs, he finally completed the required medicine according to Chen Mo's intention.

They named the drug they developed HX3.

Now the VFV virus in the culture dish, after adding the HX3 agent, the metabolic activity is significantly reduced within 24 hours, and the agent has reached Chen Mo's requirements.

"Successful." Xu Minsheng gave a rare smile.

"Successful." Several surrounding researchers also nodded and exhaled deeply.

"You will sort out the report and hand it over to the boss. I will ask the boss how to deal with HX3 next." After that, Xu Minsheng turned and left the laboratory.