Science and Technology Library

At the Capital Institute of Biological Genetics, Wang Haoyi was in his laboratory office, watching news about the Reedman virus, and he kept thinking.

This human disaster has lasted for several months, and the worst-hit area has become unimaginably serious.

Unfortunately, his research field is to establish and optimize gene editing technology in hematopoietic stem cells and T cells, to study the characteristics of related gene editing technologies, to improve the efficiency and specificity of genes, and the main focus is on genetic diseases.

This time the Reedman virus belongs to virology, and it is not so serious in China, and they do not need to participate in the approach.

This virus has caused panic in the international community, but he is also powerless.

After reading the news, Wang Haoyi put down the newspaper and sighed.Worrying about other things is useless, doing your own research is the main topic.

Boom!!

Just as Wang Haoyi was about to start researching his own subject, an old man with glasses knocked on the door and walked quickly to him, seeing that there was something urgent.

"Director Liu, is there an emergency?"

"Academician Wang, the dean is here to inform that Tangshan has achieved a breakthrough in the Ridman virus vaccine, and is now engaged in urgent technical research, and now requires genomics experts.

Hearing this notice, Wang Haoyi stood up suddenly: "I will go over."

Without waiting for Director Liu to speak again, Wang Haoyi had already begun to pack his things and was about to leave the office.

...

East China Sea Life Science Research Institute.

Yang Yunjia walked quickly into the laboratory. In the laboratory, there were members of their team, as well as students and assistants.

His team’s key R&D plan is precision medicine research projects, epigenomics detection technology and clinical applications, and new RNA methylation epitranscriptomics sequencing technologies. Both projects are under his leadership.

The hot Reedman virus outside belongs to immunology, but he is not an expert in immunology and virology, so he was not called by the medical team, and An Xin continued to preside over their research at the institute.

But just today, the capital came to inform that Tangshan's Ridman virus vaccine is progressing, and experts from genomics experts are required to participate in urgent technical research.

"Ms. Yang, what happened?" Standing still in the laboratory, other members and students looked at him, and a student asked.

"The capital needs gene editing and genomics manpower for emergency technical research. Yu Jun and Mi Shuangli, you two will go with me."

"Ms. Yang, is it convenient to say what technology is it?" the female researcher named Mi Shuangli asked.

"At the Capital Tangshan Hospital, analyzing the genes of the Reedman virus vaccine."

"it is good."

The two nodded their heads and agreed without hesitation.

The Center for Disease Control and Prevention issued a convening notice. Experts and academicians of genomics and bioinformatics who are leading research projects across the country received the news and agreed to go to the Capital Tangshan Hospital to conduct project research.

In just one day, nearly 20 genomics experts and researchers have arrived in Tangshan.

The staff of the Center for Disease Control and Prevention and the Ministry of Health knew the importance of this subject, coordinated in the center, quickly mobilized experimental equipment and materials, and prepared experimental conditions for researchers.

Tangshan Research Institute.

Chen Mo and Wu Bing, as well as the team members, entered the meeting room.

Seeing a room full of people, several team members were surprised.Some of them have been recognized, including the expert academicians of genetic immunology in the medical team. There are 33 people on the field, almost including the top group of genomics experts in China, including their former mentors.

It can be said that the group of people with the most voice in genomics in China are all in this conference room.

They are looking at everyone, and the experts below are also looking at them.Many people couldn't help but marvel at seeing Chen Mo and Wu Bing led by and the overly young team behind them.

It is this young team that has made considerable achievements in the two bioterrorists, and this time it has made breakthrough progress under the circumstances that they are not optimistic.Seeing that there are students of their own among the group members, some academicians smile with satisfaction, at least their students are promising and they are also very proud.

However, compared with Chen Mo who took the lead, it seemed that all geniuses had become bleak, and everyone's eyes quickly fell on Chen Mo.

I only heard the name in the past, but didn't see the person. I finally saw it today.

Chen Mo also scanned the experts and researchers on the field.

Their group can also find the toxic protein by themselves, but in order to speed it up, more people will obviously be faster.This time, the Center for Disease Control and the Ministry of Health coordinated, supported by the two hospitals, and found so many researchers, which was beyond his expectation.

After distributing all the materials, Chen Mo walked to the podium in the conference room and directly entered the topic.

"This morning, we performed another blood test on the patient, and you have the results. The patient has regained initial consciousness, and the antibody concentration in his body has increased compared with two days ago, and the number of viruses is decreasing. In theory, within five days or so, patients will be able to develop resistance to the Reedman virus."

After Chen Mo spoke, everyone listened carefully to Chen Mo's explanation. There were many people on the court who were old enough to be Teacher Chen Mo's teacher, but Chen Mo's performance was good enough to be their teacher.It was under his auspices that the Ridman virus vaccine made a breakthrough. No one dared to take it lightly because of Chen Mo's age.

Many people were a little happy to hear that the vaccine was effective, but they were interrupted by Chen Mo when they were surprised.

"But we detected two toxic proteins in the patient's body. These two toxic proteins increased with the increase in the concentration of antibodies. Just two hours ago, the patient died in pain. After waiting less than five days, He was not killed by the Reedman virus, but the toxic protein in his body caused him to die.

Our preliminary judgment is that this toxic protein is caused by the potential toxic protein gene in the mRNA of the vaccine platform system.So next, your task is to find these two toxic protein genes in the vaccine, and we will find ways to knock out these two genes and eliminate the toxicity of the vaccine."

"Academician Chen, are there any drugs to degrade these two toxic proteins to achieve the purpose of treatment."

Hearing the interruption of the question below, Chen Mo nodded and replied: "We have thought about this method. The medical team is looking for a drug that degrades toxins, but it has not been found so far, and it also treats the symptoms and not the root cause."

"Academician Chen, is there a sample of toxic protein?" Yang Yun's sitting in the first row asked.

"Yes, we have isolated some samples in the blood of patients, but not many. After the project starts, samples of the toxin protein will be distributed to various laboratories. Next, I will explain to you the relevant characteristics of the detoxification protein and mRNA. Relevant materials. If you have any questions, you can interrupt to ask me or ask Academician Wu, if conditions permit, we will try our best to answer you."

After the explanation, Chen Mo began to talk about some of the characteristics of the toxin protein, as well as information related to mRNA, so that they could start research.